Epidemiology

This project aims to develop methods and software for performing spatio-temporal analysis of cancer incidence and smoking data in Ontario over long time periods with high spatial resolution. This will allow changes of cancer incidence over time to be better understood, and accommodate rare cancers that require long study periods in order to accumulate data. Because of small counts common to small area analysis, computationally intensive Bayesian inference methods will be needed.

A major pharmaceutical intervention for management of many infectious diseases is the use of antiviral drugs. However, the rise of drug resistance poses significant threats to the effectiveness of drugs. This research proposes to determine optimal treatment strategies, through the development of population dynamical models for disease transmission and control, which can minimize the effect of resistance emergence in the population. This work will primarily focus on influenza infection, which still inflicts substantial morbidity, mortality, and socioeconomic costs worldwide.

Using modern statistical measurement error methodologies and analysis, we aim to efficiently and accurately discover and characterize predictive models of responses associated with abnormal growth development in young children and adults. This proposal is unique in scope and vision by addressing health issues that threaten the sustainability of the health care system.

Assembled at the height of the SARS outbreak in 2003, this project develops a variety of modeling templates.